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Updated: Aug 30, 2026

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
Published on: February 25, 2022
Enhancement of synchronization in a hybrid neural circuit by spike-timing dependent plasticity
Thomas Nowotny1, Valentin P Zhigulin, Allan I Selverston
1Institute for Nonlinear Science, University of California San Diego, La Jolla, California 92093-0402, USA. tnowotny@ucsd.edu
Abstract:
Synchronization of neural activity is fundamental for many functions of the brain. We demonstrate that spike-timing dependent plasticity (STDP) enhances synchronization (entrainment) in a hybrid circuit composed of a spike generator, a dynamic clamp emulating an excitatory plastic synapse, and a chemically isolated neuron from the Aplysia abdominal ganglion. Fixed-phase entrainment of the Aplysia neuron to the spike generator is possible for a much wider range of frequency ratios and is more precise and more robust with the plastic synapse than with a nonplastic synapse of comparable strength. Further analysis in a computational model of Hodgkin-Huxley-type neurons reveals the mechanism behind this significant enhancement in synchronization. The experimentally observed STDP plasticity curve appears to be designed to adjust synaptic strength to a value suitable for stable entrainment of the postsynaptic neuron. One functional role of STDP might therefore be to facilitate synchronization or entrainment of nonidentical neurons.
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