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Considering therapeutic options in the real world.
1Pulmonary Division, Department of Medicine, National Jewish Medical and Research Center, and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA.
The Journal of Allergy and Clinical Immunology
|October 31, 2003
Summary
Physicians face challenges in asthma treatment selection. Daily controller medications, particularly inhaled corticosteroids (ICSs), are effective, but some patients benefit from combination therapy with ICS and long-acting beta-agonists (LABAs).
Area of Science:
- Pulmonology
- Pharmacology
Background:
- Persistent asthma symptoms often require daily controller medications to prevent exacerbations.
- Inhaled corticosteroids (ICSs) are the primary treatment for asthma-related inflammation.
- Some patients remain symptomatic despite adequate ICS dosing.
Purpose of the Study:
- To review treatment options for persistent asthma.
- To highlight the role of combination therapy and alternative anti-inflammatory agents.
Main Methods:
- Literature review of asthma treatment guidelines and clinical trial data.
- Analysis of the efficacy of inhaled corticosteroids (ICSs), long-acting beta-agonists (LABAs), and leukotriene receptor antagonists (LTRAs).
Main Results:
- Daily controller medications improve outcomes for persistent asthma.
- ICSs are effective for underlying inflammation.
- Combination therapy (ICS/LABA) and LTRAs offer alternatives for inadequately controlled asthma.
Conclusions:
- Treatment selection for persistent asthma involves balancing clinical experience and trial data.
- Combination therapy (ICS/LABA) may benefit patients unresponsive to ICS alone.
- Leukotriene receptor antagonists (LTRAs) provide another anti-inflammatory option, alone or with ICS.
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