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Folic acid-conjugated nanostructured materials designed for cancer cell targeting
Dipanjan Pan1, Jeffrey L Turner, Karen L Wooley
1Department of Chemistry, Washington University, One Brookings Drive, CB 1134, Saint Louis, Missouri 63130, USA.
Chemical Communications (Cambridge, England)
|November 1, 2003
Abstract:
Shell cross-linked nanoparticles (SCKs) constitute a unique class of materials with amphiphilic core-shell morphology; SCKs are characterised by their structural integrity and available functionality to attach receptor-recognising or receptor-specific ligands on the shell surface and, therefore, hold great potential in drug delivery applications; in an attempt to develop novel, cancer cell specific delivery vehicles, folate receptor targeted SCKs have been prepared.