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Endometrial dating in the conception cycle.
K Andoh1, H Mizunuma, Y Nakazato
1Department of Obstetrics and Gynecology, Gunma University, School of Medicine, Japan.
Fertility and Sterility
|December 1, 1992
Summary
Endometrial dating in conception cycles is in-phase until day 12 post-luteinizing hormone (LH) surge. After day 12, apparent out-of-phase findings in endometrial biopsies may indicate early pregnancy.
Area of Science:
- Reproductive Endocrinology
- Gynecology
Background:
- Accurate endometrial dating is crucial for assessing reproductive success.
- The luteal phase, particularly after the luteinizing hormone (LH) surge, is a critical window for implantation.
Purpose of the Study:
- To investigate the accuracy of endometrial dating during the conception cycle.
- To correlate endometrial biopsy findings with conception and progesterone levels.
Main Methods:
- Endometrial biopsies were collected during the luteal phase of 185 women undergoing fertility treatment.
- Biopsies were dated based on urinary LH surge, and correlated with serum progesterone levels.
Main Results:
- Women who conceived had in-phase endometrial biopsies 7-11 days after the LH surge.
- On day 12 post-LH surge, 4 out of 5 women who conceived showed delayed stromal development, suggesting a link to conception.
Conclusions:
- Endometrial dating is reliable until day 12 of the luteal phase in conception cycles.
- Apparent out-of-phase endometrial development on day 12 may be an early indicator of gestational hyperplasia.