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M129V variation in the prion protein may influence cognitive performance
D Rujescu1, A M Hartmann, C Gonnermann
1Division of Molecular Neurobiology, Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany. Dan.Rujescu@psy.med.uni-menchen.de
Molecular Psychiatry
|November 1, 2003
Summary
A common genetic variation in the prion protein gene is linked to differences in general intelligence (g) and cognitive performance, specifically Full Scale IQ scores. Further research is needed to confirm these findings on cognitive abilities.
Area of Science:
- Neurogenetics
- Cognitive Neuroscience
- Psychiatry
Background:
- General intelligence (g) shows moderate correlations with brain volume, with genetic factors influencing white matter volume.
- Previous research identified an association between a prion protein gene polymorphism (methionine at codon 129) and reduced white matter volume.
Purpose of the Study:
- To investigate the influence of the prion protein gene polymorphism on cognitive performance in healthy volunteers.
- To explore the relationship between genetic variation, brain structure, and cognitive abilities.
Main Methods:
- Studied 335 healthy community-based volunteers.
- Assessed cognitive performance using the German version of the Wechsler Adult Intelligence Scale, Revised (HAWIE-R).
- Analyzed the association between a specific prion protein gene polymorphism and HAWIE-R scores.
Main Results:
- The prion protein gene polymorphism was significantly associated with Full Scale IQ scores (P=0.013 for genotype, P=0.005 for allele).
- The genotype explained 2.7% of the total variability in Full Scale IQ.
- An exploratory analysis indicated associations with several HAWIE-R subscales, with the Digit Symbol subtest remaining significant after multiple testing correction.
Conclusions:
- Evidence suggests a link between a common genetic variation in the prion protein gene and cognitive performance.
- Independent replication is required to solidify these findings regarding genetic influences on intelligence and cognitive function.