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Hydroxyapatite crystal deposition disease.

Glenn M Garcia1, Gary C McCord, Rajendra Kumar

  • 1Department of Radiology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA.

Seminars in Musculoskeletal Radiology
|November 1, 2003
PubMed
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Hydroxyapatite (HA) crystal deposition disease (HADD) involves HA crystal buildup in joints, causing pain and swelling. Treatment includes pain relief, aspiration of deposits, and sometimes surgery.

Area of Science:

  • Rheumatology
  • Orthopedics
  • Crystal Arthropathies

Background:

  • Hydroxyapatite (HA) crystal deposition disease (HADD) is a systemic condition of unknown cause.
  • It results from the deposition of HA crystals in or around joints, leading to inflammation and pain.

Purpose of the Study:

  • To describe the clinical manifestations, radiographic findings, and treatment options for HADD.
  • To highlight the common involvement of the shoulder joint and its association with Milwaukee shoulder.

Main Methods:

  • Review of clinical cases and radiographic evidence of HADD.
  • Analysis of the distribution and characteristics of HA crystal deposits.
  • Evaluation of treatment outcomes for various interventions.

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Main Results:

  • HADD presents with localized pain, swelling, and limited joint motion, though some patients are asymptomatic.
  • Radiographs often reveal calcifications in tendons, bursae, and joint capsules, with the shoulder (supraspinatus tendon) being most commonly affected.
  • Intra-articular HA crystals can lead to joint destruction, as seen in Milwaukee shoulder.

Conclusions:

  • HADD is a significant cause of joint pain and dysfunction, particularly affecting the shoulder.
  • Early diagnosis and appropriate management, including analgesics, aspiration, and injections, are crucial for symptom relief.