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Published on: July 8, 2025
[Spastic tetraparesis as a sequela of bacterial meningitis]
S V T-Barros1, T A-Beherens, A R-Cardozo
1Unidad de Neurología Infantil, Servicio de Pediatría, Hospital de Clínicas de Porto Alegre, UFRGS, Porto Alegre, Brasil.
Insights
Spastic tetraparesis (ST) occurred in 15.1% of pediatric meningitis cases. Patients with ST experienced longer hospital stays and more frequent seizures and intracranial hypertension.
Area of Science:
- Neurology
- Pediatrics
- Infectious Diseases
Context:
- Meningitis is a serious infection affecting the central nervous system in children.
- Spastic tetraparesis (ST) is a potential neurological complication of meningitis.
- Understanding the incidence and associated factors of ST is crucial for pediatric intensive care.
Purpose:
- To determine the incidence of spastic tetraparesis (ST) in pediatric meningitis patients.
- To identify variables associated with the development of ST.
- To compare findings with existing literature on meningitis complications.
Summary:
- A retrospective review of 112 pediatric meningitis cases in an ICU from 1985-2001 identified an incidence of 15.1% for cerebral palsy, specifically spastic tetraparesis (ST).
- Patients who developed ST had significantly longer hospitalizations, increased frequency of seizures, intracranial hypertension, and higher cerebrospinal fluid protein levels (p<0.05).
- The study examined etiological agents, demographics, and treatment in relation to ST development.
Impact:
- This study highlights the significant neurological sequelae of pediatric meningitis, particularly ST.
- Findings can inform clinical management and prognostication for children with meningitis.
- Provides valuable data for understanding long-term neurological outcomes in pediatric intensive care settings.
Aims:
The aim of this study is to demonstrate the incidence of spastic tetraparesis (ST) in meningitis patients in the paediatric ICU, together with the associated variables, and establish comparisons with the existing literature.
Patients And Methods:
We reviewed the medical records of patients who presented symptoms of meningitis and required hospital treatment in the Paediatric ICU at the Hospital de Clínicas de Porto Alegre, between January 1985 and June 2001. In addition to the diagnosis of meningitis and the incidence of ST as a complication, we also examined the aetiological agent, sex, age at the moment of hospital admittance, length of time spent in hospital and treatment given in each case. RESULTS AND DISCUSSION. An incidence of 15.1% was found for cerebral palsy in the 112 cases of bacterial meningitis that were followed up clinically. In the patients with ST, the time spent in hospital was longer, and the frequency of seizures, intracranial hypertension and the protein concentration levels in CSF were higher (p<0.05).
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