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Updated: Aug 1, 2026

Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
Small-molecule inhibitors of the cell cycle: an overview
Craig M Crews1, J Brad Shotwell
1Department of Molecular, Cellular, and Developmental Biology, Department of Chemistry, Department of Pharmacology, Yale University, New Haven, CT 06520, USA.
Abstract:
Potent and selective small-molecule mediated inhibition of the cell's replication machinery remains a principal aim in the development of novel therapeutics and biological probes. Recent efforts have identified small molecules capable of arresting the cell cycle via specific interaction with a variety of intracellular protein targets. Advances in combinatorial and diversity oriented synthetic methods, coupled with a continued effort to identify sources of bioactive natural products, promise to contribute to the growing library of small-molecule inhibitors of the cell cycle.
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