Related Experiment Video
Updated: Aug 30, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
Published on: June 6, 2017
The role of cytosolic phospholipase A2 in cell cycle progression
Johannes Boonstra1, Gerda S van Rossum
1Department of Molecular Cell Biology, University Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
Abstract:
Cytosolic phospholipase A2 (cPLA2) cleaves fatty acids from the sn-2 position of phospholipids resulting in the release of arachidonic acid. cPLA2 is activated upon phosphorylation, followed by a Ca(2+)-dependent translocation to cellular membranes. The activity of cPLA2 has been demonstrated to fluctuate during the M, G1 and S-phases of the cell cycle, and it has been shown recently that inhibition of the relatively high activity during the initial phases of the cell cycle results in a drastic reduction in S-phase entry. These findings demonstrate that in addition to a role in the inflammatory response, cPLA2 plays also an important regulatory role in cell cycle progression.
Related Concept Videos
Positive Regulator Molecules
Positive Regulator Molecules
Molecular Factors Affecting Cell Division
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Inhibition of Cdk Activity
Inhibition of CDK Activity
The Cell Cycle Control System
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...

