Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulators of nucleolar functions.

Danièle Hernandez-Verdun1, Pascal Roussel

  • 1Institut Jacques Monod, 2 place Jussieu, 75251 Paris, France.

Progress in Cell Cycle Research
|November 5, 2003
PubMed
Summary

The nucleolus, essential for ribosome biogenesis and cell growth, dynamically regulates RNA synthesis and processing. Its function is tightly controlled by cell cycle kinases, especially during mitosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanochemically assembled organometallic complexes: a mechanistic study.

Chemical science·2026
Same author

Sirtuin inhibition by plumbagin connects protein acetylation to cell division.

Journal of cell science·2026
Same author

Isoniazid-derived vanillin and Salicylaldehyde Hydrazones: Promising Antimycobacterials with KatG-dependent activation.

Bioorganic chemistry·2026
Same author

Integrated Electrochemical Conversion of Plastic Waste and CO<sub>2</sub> to Formate Using Non-Noble-Metal Catalysts: <i>In Situ</i> Raman Study.

ACS applied materials & interfaces·2025
Same author

Design, Synthesis, and Biological Evaluation of Triazolopyrimidine-Isatin Hybrids as Promising Candidates for Triple-Negative Breast Cancer.

Archiv der Pharmazie·2025
Same author

Rigidity-Driven Structural Isomers in the NaCl-Ga<sub>2</sub>S<sub>3</sub> System: Implications for Energy Storage.

Small science·2025

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • The nucleolus is a key nuclear domain responsible for ribosome biogenesis.
  • Ribosome biogenesis is crucial for cell growth and proliferation.
  • Nucleolar function is dynamic, balancing ribosomal RNA synthesis and processing.

Purpose of the Study:

  • To investigate the regulation of nucleolar function during the cell cycle.
  • To understand the role of cyclin-dependent kinases in nucleolar dynamics.
  • To elucidate the mechanisms controlling ribosome biogenesis cessation during mitosis.

Main Methods:

  • Analysis of nucleolar dynamics during interphase and mitosis.
  • Investigating the impact of cell cycle regulators on transcription and processing.
  • Utilizing molecular biology techniques to study protein interactions and gene expression.

Main Results:

  • Ribosome biogenesis is regulated throughout interphase and ceases during mitosis.
  • Mitotic silencing of transcription and processing machinery distribution are dependent on cyclin-dependent kinases.
  • The link between transcription and processing is modulated by cell cycle kinases.

Conclusions:

  • Cyclin-dependent kinases play a critical role in regulating nucleolar function and ribosome biogenesis.
  • The cell cycle controls ribosome production through precise regulation of transcription and processing.
  • Understanding these mechanisms is vital for comprehending cell growth and proliferation control.

Related Experiment Videos