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Survivin in apoptosis control and cell cycle regulation in cancer

Dario C Altieri1

  • 1Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.

Progress in Cell Cycle Research
|November 5, 2003
PubMed

Insights

Survivin, a molecule found in most human cancers, plays a role in apoptosis evasion and uncontrolled cell proliferation. Targeting the survivin pathway shows promise for novel cancer diagnosis and therapies.

Area of Science:

  • Molecular biology
  • Oncology
  • Biochemistry

Background:

  • All human cancers exhibit evasion of apoptosis and uncontrolled proliferation.
  • Survivin is a molecule located at the intersection of apoptosis regulation and cell proliferation control.
  • Survivin is expressed in most human cancers, but not in normal tissues.

Purpose of the Study:

  • To investigate the role of survivin in cancer.
  • To explore the potential of the survivin pathway for cancer diagnosis and therapy.

Main Methods:

  • Analysis of survivin expression in cancer and normal tissues.
  • Review of existing studies on survivin's function and therapeutic potential.

Main Results:

  • Survivin is differentially expressed in cancer versus normal tissues.
  • The survivin pathway presents opportunities for therapeutic intervention.

Conclusions:

  • Survivin is a promising target for cancer diagnosis and treatment.
  • Further research into the survivin pathway could lead to significant advancements in oncology.

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