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Updated: Jul 17, 2026
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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
Published on: September 12, 2011
Abnormal brain lateralization in high-functioning autism
Paul R Escalante-Mead1, Nancy J Minshew, John A Sweeney
1University of Illinois at Chicago, Chicago, IL 60612, USA.
Journal of Autism and Developmental Disorders
|November 5, 2003
Summary
Autism is linked to atypical brain development, specifically in establishing lateral preference. This study found that autistic individuals with early language issues show more disturbed cerebral dominance, suggesting a maturational issue rather than just left-handedness.
Area of Science:
- Neuroscience
- Developmental Psychology
- Autism Spectrum Disorder Research
Background:
- Lateral preference, or handedness, is a key indicator of cerebral dominance.
- Understanding atypical lateral preference in autism may reveal insights into brain maturation processes.
- Language development is often affected in individuals with autism spectrum disorder (ASD).
Purpose of the Study:
- To investigate the relationship between lateral preference disturbances and early language development in autism.
- To compare cerebral dominance patterns in autistic individuals with and without a history of language issues against healthy controls.
- To determine if atypical lateral preference in autism reflects maturational disturbances or increased left-handedness.
Main Methods:
- Utilized the Edinburgh Handedness Inventory, a standardized measure of lateral preference.
- Compared 47 autistic individuals with disordered early language development and 22 autistic individuals with normal early language acquisition.
- Matched autistic participants with 112 typically developing healthy individuals for comparison.
Main Results:
- Autistic individuals with a history of early language disturbance exhibited significantly more atypical cerebral dominance compared to healthy controls.
- Atypical cerebral dominance was also more pronounced in this subgroup of autistic individuals than in autistic individuals with normal early language skills.
- The findings suggest maturational disturbances in the establishment of lateral preference, not simply an increased prevalence of left-handedness.
Conclusions:
- Atypical establishment of cerebral dominance is associated with disordered language development in autism spectrum disorder.
- These findings highlight potential neurodevelopmental differences in brain organization related to lateralization in autism.
- Further research into lateral preference may offer novel avenues for understanding and supporting language development in autistic individuals.
Related Concept Videos
01:05Cerebral Hemispheres
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
01:28Lateralization
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
01:19Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
01:30Attention-Deficit/Hyperactivity Disorder
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.