Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Annular epidermolytic ichthyosis.

Narayan S Naik1

  • 1Ronald O. Perelman Department of Dermatology, New York University, USA.

Dermatology Online Journal
|November 5, 2003
PubMed
Summary
This summary is machine-generated.

This study reports a rare case of palmoplantar keratoderma with widespread psoriasiform patches, highlighting a unique phenotype. Genetic analysis revealed mutations in keratin 1 and 10, consistent with epidermolytic hyperkeratosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mucocele of the neck.

The American Journal of dermatopathology·2005
Same author

Nonpseudomonal ecthyma gangrenosum.

Journal of the American Academy of Dermatology·2004
Same author

Erythema dyschromicum perstans and vitiligo.

Dermatology online journal·2003
Same journal

Pellagra associated with iron deficiency.

Dermatology online journal·2026
Same journal

Demodicosis: A frequently underrecognized cause of recalcitrant ear pruritus.

Dermatology online journal·2026
Same journal

Association of alopecia areata with COVID-19 vaccination: A vaccine adverse events reporting system analysis.

Dermatology online journal·2026
Same journal

Gender based price differences in 5% minoxidil foam: The impact of generic alternatives and bulk packaging.

Dermatology online journal·2026
Same journal

Retrospective analysis of filler complications reported in the manufacturer and user facility device experience database from 2015 to 2025.

Dermatology online journal·2026
Same journal

Characterizing barriers to care in patients with hidradenitis suppurativa.

Dermatology online journal·2026
See all related articles

Area of Science:

  • Dermatology
  • Genetics
  • Histopathology

Background:

  • Palmoplantar keratoderma (PPK) is a group of inherited skin disorders affecting the palms and soles.
  • Epidermolytic hyperkeratosis (EH) is a subtype of ichthyosis characterized by specific histopathological findings.
  • Genetic mutations in keratin genes are known causes of various keratinization disorders.

Observation:

  • A 21-year-old woman presented with lifelong PPK and episodic, widespread psoriasiform skin lesions.
  • Histopathological examination of skin biopsy revealed epidermolytic hyperkeratosis.
  • This specific clinical presentation is exceptionally rare, documented in only seven families previously.

Findings:

  • The patient's phenotype is associated with mutations in keratin 1 (KRT1) and keratin 10 (KRT10) genes.

Related Experiment Videos

  • These genetic findings align with those observed in individuals with classic epidermolytic hyperkeratosis.
  • The study identifies a specific KRT1/KRT10 mutation pattern linked to this rare PPK variant.

    • Implications:

    • This case expands the known spectrum of KRT1/KRT10-associated genodermatoses.
    • Understanding these mutations aids in accurate diagnosis and genetic counseling for rare skin conditions.
    • Further research into genotype-phenotype correlations can improve management strategies for epidermolytic hyperkeratosis variants.