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Updated: Aug 30, 2026

Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System
Published on: March 18, 2010
Physical and functional interaction of the Werner syndrome protein with poly-ADP ribosyl transferase
Caroline Adelfalk1, Maria Kontou, Monica Hirsch-Kauffmann
1Free University of Berlin, Department of Biochemistry, Thielallee 63, D-14195 Berlin, Germany. adelfalk@molgen.mpg.de
Abstract:
Werner's syndrome is a rare disease of premature ageing. The WRN gene product defective in this disorder belongs to the RecQ helicase family and is thought to be involved in DNA metabolism. Another protein, which plays an important role in both DNA replication and repair, is the poly-ADP ribosyl transferase. Here we demonstrate an interaction of these two proteins resulting in ADP-ribosylation of the WRN protein. These results imply that WRN is involved in DNA replication and in DNA repair.
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