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Regional outbreak of parvovirus B19 acute myocarditis in preschool children

Filippos-Paschalis Rorris1, Maria Kontou2, Meletios Kanakis1

  • 1Department of Pediatric and Adult Congenital Heart Surgery Onassis Cardiac Surgery Center Athens Greece.

Pediatric Investigation
|June 20, 2025
PubMed

Insights

An outbreak of parvovirus B19 caused severe acute myocarditis in young children in Greece, leading to high rates of illness and death. Affected children experienced critical heart dysfunction requiring intensive care.

Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Virology

Background:

  • An unusual cluster of acute myocarditis cases was identified in preschool children in northern Greece.
  • Parvovirus B19 was identified as the likely causative agent.
  • The outbreak presented with significant morbidity and mortality.

Discussion:

  • The affected children demonstrated severely impaired left ventricular ejection fraction.
  • All patients required intensive care unit admission and inotropic support.
  • This highlights a severe presentation of parvovirus B19 infection in a pediatric population.

Key Insights:

  • Parvovirus B19 can cause severe, life-threatening acute myocarditis in young children.
  • Early recognition and intensive supportive care are crucial for managing these cases.
  • Geographic clustering suggests potential environmental or epidemiological factors.

Outlook:

  • Further research is needed to understand the specific mechanisms of parvovirus B19-induced myocarditis in children.
  • Surveillance for similar outbreaks in other regions is warranted.
  • Development of targeted interventions or preventative strategies may be considered.

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