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Sorting motifs in receptor trafficking.
1Department Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72005, USA. KurtenRichardC@uams.edu
Advanced Drug Delivery Reviews
|November 5, 2003
Summary
Receptor sorting motifs control cellular uptake and function. Identifying these motifs in receptors like LDL, transferrin, and signaling receptors offers targets for therapeutic intervention.
Area of Science:
- Cellular Biology
- Molecular Biology
- Biochemistry
Background:
- Receptor sorting motifs are crucial for cellular processes.
- Early research identified motifs in LDL and transferrin receptors for internalization.
- These motifs are conserved across various receptors, influencing diverse sorting functions.
Purpose of the Study:
- To review early studies on LDL and transferrin receptor sorting.
- To focus on sorting motifs in signaling receptors: receptor tyrosine kinases and G-protein coupled receptors.
- To discuss motif-binding proteins and potential therapeutic targets.
Main Methods:
- Literature review of early receptor internalization studies.
- Analysis of sorting motifs in cytoplasmic tails/domains of various receptors.
- Focus on receptor tyrosine kinases (EGF, insulin) and G-protein coupled receptors (beta2-adrenergic).
Main Results:
- Sorting motifs identified in LDL and transferrin receptors mediate internalization.
- These motifs are present in a wide array of receptors, enabling diverse sorting functions.
- Identification of specific motifs and their binding proteins in signaling receptors.
Conclusions:
- Sorting motifs are fundamental to receptor trafficking and function.
- Understanding these motifs in signaling receptors provides insights into their activity.
- Potential targets for modulating receptor sorting and activity in disease are identified.