Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synaptic structure and diffusion dynamics of synaptic receptors.

Antoine Triller1, Daniel Choquet

  • 1Biologie Cellulaire de la Synapse N&P, INSERM U497, Ecole Normale Supérieure, Paris, France. triller@wotan.ens.fr

Biology of the Cell
|November 5, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metal Neurotoxicity assessment: a new imaging and analysis pipeline for primary neurons in co-cultures.

Journal of neuroscience methods·2026
Same author

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post-Synapses of Neurons and Enhanced Uptake in Astrocytes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Synapse-specific and plasticity-regulated AMPA receptor mobility tunes synaptic integration.

Neuron·2026
Same author

Competition between glycine and GABA<sub>A</sub> receptors for gephyrin controls their equilibrium populations at inhibitory synapses.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Synaptic pruning following NMDAR-dependent LTD preferentially affects isolated synapses.

iScience·2025
Same author

AMPA receptor diffusional trapping machinery as an early therapeutic target in neurodegenerative and neuropsychiatric disorders.

Translational neurodegeneration·2025

Neurotransmitter receptor distribution at synapses is a dynamic balance. Lateral membrane diffusion, alongside endocytosis, is crucial for regulating receptor numbers and function during synaptic plasticity.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Synaptic Plasticity

Background:

  • Neurotransmitter receptors are localized at synapses via scaffolding proteins and cytoskeleton.
  • Receptors exist in synaptic, intracellular, and dispersed membrane pools.
  • Receptor distribution is increasingly viewed as a dynamic equilibrium.

Purpose of the Study:

  • To review the mechanisms regulating neurotransmitter receptor distribution.
  • To highlight the role of lateral membrane diffusion in synaptic receptor dynamics.
  • To connect receptor trafficking to synaptic plasticity.

Main Methods:

  • Review of existing literature on receptor trafficking and synaptic function.
  • Analysis of data on receptor stabilization and accumulation at synapses.

Related Experiment Videos

  • Discussion of endo/exocytotic processes and lateral diffusion.

    • Main Results:

    • Neuronal activity and scaffolding proteins regulate receptor pool equilibrium.
    • Changes in equilibrium lead to rapid variations in synaptic receptor numbers.
    • Lateral diffusion is a key mechanism for receptor stabilization and synaptic accumulation.

    Conclusions:

    • Synaptic receptor levels are dynamically regulated by multiple trafficking pathways.
    • Lateral diffusion plays a significant role in synaptic receptor stabilization, complementing endo/exocytosis.
    • Understanding these dynamics is essential for comprehending synaptic plasticity.