Related Experiment Videos
Recent advances in therapeutic apheresis
1Nephrology Division, Department I of Internal Medicine, University Hospital Munich-Grosshadern, D-81377 Munich, Germany. Bosch@med1.med.uni-muenchen.de
Summary
Therapeutic apheresis advances, including endotoxin adsorption and LDL apheresis, show promise in treating conditions like rheumatoid arthritis and sudden hearing loss. New devices and techniques improve efficacy and patient outcomes.
Area of Science:
- Medical Technology
- Nephrology
- Cardiology
Background:
- Therapeutic apheresis has seen advancements in techniques, indications, and understanding.
- New devices for endotoxin adsorption and lipid removal have been developed.
Purpose of the Study:
- To review recent innovations and clinical applications of therapeutic apheresis.
- To highlight the efficacy of various apheresis methods in different medical conditions.
Main Methods:
- Prospective randomized controlled trials and noncontrolled trials were used.
- Evaluated devices include endotoxin adsorbers, Prosorba columns, heparin-induced extracorporeal LDL precipitation (HELP), immunoadsorption, rheopheresis, and direct adsorption of lipids (DALI)-LDL apheresis.
Main Results:
- Endotoxin adsorber apheresis improved APACHE II scores.
- Prosorba column apheresis showed significant improvement in rheumatoid arthritis patients.
- HELP treatment was superior for sudden hearing loss with elevated LDL.
- Immunoadsorption showed promise in dilated cardiomyopathy and kidney transplant rejection.
- Rheopheresis was effective for age-related macular degeneration.
- DALI-LDL apheresis demonstrated safety, efficacy, and reduced treatment times.
Conclusions:
- Recent therapeutic apheresis innovations offer improved treatment options for various critical conditions.
- Technical advancements in apheresis devices enhance their effectiveness and patient applicability.