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Related Experiment Videos

[Use of phenomenon of adsorption decrease in solid cohesion for remote lithotripsy (experimental study)].

A V Kasaikin, Iu V Olefir, E S Shpilenia

    Voenno-Meditsinskii Zhurnal
    |November 6, 2003
    PubMed
    Summary

    Researchers explored the Rebinder effect for non-invasive kidney stone destruction. Urine surface activity differs between healthy individuals and those with kidney stones, impacting stone breakdown efficiency. Chlorhexidine solutions enhanced stone destruction.

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    Area of Science:

    • Colloid chemistry
    • Biophysics
    • Urology

    Background:

    • The Rebinder effect, a decrease in solid cohesion due to adsorption, is a known phenomenon in colloid chemistry.
    • Kidney stones (nephrolithiasis) pose a significant health challenge, necessitating effective treatment strategies.
    • Understanding the interaction between biological fluids and stone surfaces is crucial for developing novel therapeutic approaches.

    Purpose of the Study:

    • To investigate the potential of the Rebinder effect for remote, non-invasive destruction of kidney stones.
    • To compare the sorption properties of urine from healthy individuals and those with urolithiasis.
    • To evaluate the efficacy of synthetic surfactants in facilitating kidney stone fragmentation.

    Main Methods:

    • Measurement of bordering moistening angles to assess surface activity.

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  • In vitro experiments to determine the efficiency of remote nephrolith destruction.
  • Comparative analysis of urine samples from healthy subjects and urolithiasis patients.
  • Testing various synthetic surfactants and chlorhexidine bigluconate solutions.

    • Main Results:

    • Urine from healthy individuals exhibited higher surface activity than urine from urolithiasis patients.
    • A correlation was established between the bordering moistening angle of the immersion liquid and in vitro stone destruction efficiency.
    • The efficiency of nephrolith destruction was significantly enhanced in water solutions of chlorhexidine bigluconate.

    Conclusions:

    • The Rebinder effect shows promise for non-invasive kidney stone treatment.
    • Surface activity of biological fluids, like urine, plays a role in the efficacy of stone destruction.
    • Chlorhexidine bigluconate demonstrates potential as a medium for enhancing non-invasive kidney stone fragmentation.