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Haemoglobin A1c: analysis and standardisation.

¹Department of Clinical Biochemistry, Norfolk and Norwich University Hospital, Colney Lane, Norwich, UK. g.john@nnuh.nhs.uk

Clinical Chemistry and Laboratory Medicine

|November 6, 2003

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Glycated haemoglobin measurement is vital for diabetes monitoring. This paper reviews current lab methods and introduces the new IFCC standard for accurate glycated haemoglobin testing.

Area of Science:

Clinical Chemistry
Diabetology
Analytical Biochemistry

Background:

Glycated haemoglobin (HbA1c) is a key biomarker for monitoring long-term glycaemic control in patients with diabetes mellitus.
Variability in analytical techniques has led to diverse reporting of glycated haemoglobin fractions (e.g., HbA1, HbA1c, total glycated haemoglobin) across laboratories.
Standardization is crucial for consistent and reliable patient management.

Observation:

Multiple analytical methods are currently employed in clinical laboratories for measuring glycated haemoglobin.
These methods differ in the specific glycated haemoglobin fraction they quantify.
The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has developed a new reference method.

Findings:

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The paper provides an overview of the principles underlying currently used clinical laboratory methods for glycated haemoglobin measurement.

It details the new IFCC reference method, designed to standardize future laboratory practices.

Discussion includes analytical goals and potential interfering factors affecting measurement accuracy.

Implications:

The adoption of the IFCC reference method promises to enhance the standardization of glycated haemoglobin testing globally.
Improved standardization will lead to more accurate and consistent monitoring of glycaemic control in diabetic patients.
This facilitates better clinical decision-making and improved patient outcomes in diabetes management.