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Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
Published on: February 16, 2020
Emerging blood-based diagnostic strategies for tuberculosis
Chunlin Yue1, Xiaoxia Geng2, Xiaoyu Sun1
1Department of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Abstract:
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global public health challenge. Rapid and accurate diagnostic methods are critical for effective TB control. In recent years, serological diagnosis has attracted growing attention with the continuous identification of novel biomarkers, owing to its simplicity, rapid turnaround, and cost-effectiveness, particularly for the diagnosis of extrapulmonary TB (EPTB) and in individuals who test negative by sputum culture and rapid molecular assays. In this review, we summarize current biomarkers used in TB serodiagnosis, discuss the integration of advanced diagnostic technologies, and highlight their potential to improve TB diagnosis across diverse clinical settings.
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