Related Experiment Videos
Dietary sesame lignans decrease lipid peroxidation in rats fed docosahexaenoic acid.
Saiko Ikeda1, Mieko Kagaya, Katsura Kobayashi
1Department of Food and Nutrition, Sugiyama Jogakuen University, Nagoya 464-8662, Japan.
Journal of Nutritional Science and Vitaminology
|November 6, 2003
Summary
Dietary sesame lignans, sesamin and sesaminol, reduce lipid peroxidation in rats. These compounds increase alpha-tocopherol levels, protecting against docosahexaenoic acid-induced damage and red blood cell hemolysis.
Area of Science:
- Nutritional Biochemistry
- Lipid Metabolism
- Antioxidant Research
Background:
- Sesame lignans (sesamin, sesaminol) are known to increase alpha-tocopherol and decrease lipid peroxidation markers.
- Docosahexaenoic acid (DHA) is an omega-3 fatty acid that can promote lipid peroxidation.
Purpose of the Study:
- To investigate the effects of dietary sesamin and sesaminol on lipid peroxidation in rats fed DHA.
- To determine if sesame lignans can mitigate DHA-induced oxidative stress.
Main Methods:
- Male Wistar rats were fed diets containing DHA, sesamin, sesaminol, or combinations thereof for 5 weeks.
- Measurements included thiobarbituric acid reactive substance (TBARS) concentration and red blood cell hemolysis.
- Alpha-tocopherol concentrations in plasma, liver, and brain were analyzed.
Main Results:
- Dietary DHA increased TBARS levels and red blood cell hemolysis.
- Sesamin and sesaminol supplementation reduced TBARS concentrations and hemolysis, even in the presence of DHA.
- Sesame lignans significantly elevated alpha-tocopherol levels in plasma, liver, and brain.
Conclusions:
- Dietary sesamin and sesaminol effectively decrease lipid peroxidation in rats fed DHA.
- The protective effect is associated with increased alpha-tocopherol concentrations.
- Sesame lignans represent a potential dietary strategy to combat DHA-induced oxidative stress.