Oligosaccharides might stimulate calcium absorption in formula-fed preterm infants

Area of Science:

• Nutritional Science
• Pediatric Nutrition
• Biochemistry

Background:

• Human milk oligosaccharides are linked to efficient calcium absorption in infants.
• Dietary oligosaccharides have demonstrated improved calcium absorption in adults.
• Preterm infants have unique nutritional needs regarding mineral metabolism.

Purpose of the Study:

• To investigate the impact of dietary oligosaccharides on calcium metabolism in preterm infants.
• To assess the effect of supplemented formula on calcium and phosphorus balance.
• To evaluate plasma alkaline phosphatase activity as an indicator of bone metabolism.

Main Methods:

• A 4-week feeding study comparing standard formula with oligosaccharide-supplemented formula.
• Measurement of plasma calcium, phosphorus, and alkaline phosphatase activity.
• Analysis of calcium and phosphorus concentrations in spot urine samples.

Main Results:

• No significant differences in plasma calcium, phosphorus, or alkaline phosphatase activity between groups.
• A trend towards higher urinary calcium concentrations in infants fed the supplemented formula.
• A tendency for a higher calcium/phosphorus molar ratio in urine with oligosaccharide supplementation.

Conclusions:

• Dietary oligosaccharides may influence calcium absorption in preterm infants, indicated by urinary excretion patterns.
• Further research is warranted to understand the role of oligosaccharides in preterm infant calcium homeostasis.
• The findings suggest considering oligosaccharide effects in the nutritional management of preterm infants.