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Updated: Aug 8, 2026

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells
Published on: August 14, 2010
Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism
1Department of Pathology, Norris Comprehensive Cancer Ctr, Rm 5428, 1441 Eastlake Ave, MC9176, Los Angeles, CA 90033, USA.
Abstract:
Class switch recombination is the gene rearrangement process by which our B lymphocytes change from IgM production to IgG, IgA, or IgE. Unlike the well-characterized V(D)J recombination, the mechanism of class switch recombination has been largely enigmatic until very recent progress has begun to shed light on this gene rearrangement process. Progress has been made on the enzymes involved in leading to the DNA cleavage events and on identifying the unusual DNA structures that those enzymes recognize.
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