Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metastatic bone disease: future directions.

Denis R Clohisy1

  • 1Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Mn 55455, USA. clohi001@umn.edu

Clinical Orthopaedics and Related Research
|November 6, 2003
PubMed
Summary

New enzyme prodrug gene therapy strategies show promise for treating bone cancer, which is common and hard to cure. Current treatments like radiation and bisphosphonates offer pain relief but do not extend survival for bone cancer patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

5-fluoro-deoxyglucose PET/CT response after neoadjuvant chemotherapy predicts long-term outcomes in soft tissue sarcomas: Results from a prospective trial.

Cancer·2025
Same author

Multifocal Desmoid-Type Fibromatosis: Case Series and Potential Relationship to Neuronal Spread.

Cureus·2024
Same author

Multiple malignant tumors in a patient with familial chordoma, a case report.

BMC medical genomics·2021
Same author

Leadership, Communication, and Negotiation Across a Diverse Workforce*: An AOA Critical Issues Symposium.

The Journal of bone and joint surgery. American volume·2017
Same author

Management of Unplanned Excision for Soft-Tissue Sarcoma With Preoperative Radiotherapy Followed by Definitive Resection.

American journal of clinical oncology·2014
Same author

Pilot study of vascular health in survivors of osteosarcoma.

Pediatric blood & cancer·2013

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Bone cancer presents significant treatment challenges, with current therapies offering limited survival benefits.
  • Existing bone-targeted treatments, such as radiation and bisphosphonates, primarily manage pain and lack substantial tumor-killing efficacy.
  • Bisphosphonates, targeting osteoclasts, are ineffective against tumor cells in bone cancer patients.

Purpose of the Study:

  • To explore novel therapeutic strategies for bone cancer, addressing the limitations of current treatments.
  • To investigate the potential of enzyme prodrug gene therapy for bone cancer treatment.
  • To identify new treatment options for patients with bone metastases or at high risk.

Main Methods:

  • Review of current bone-targeted therapies including radiation and bisphosphonates.

Related Experiment Videos

  • Exploration of enzyme prodrug gene therapy as a novel treatment modality.
  • Analysis of the efficacy and limitations of existing bone cancer treatments.

    • Main Results:

    • Current bone cancer therapies provide inadequate survival benefits.
    • Bisphosphonates demonstrate limited tumor-killing properties in human bone cancer.
    • Enzyme prodrug gene therapy is under investigation as a potential new treatment avenue.

    Conclusions:

    • There is a critical need for innovative treatments for bone cancer.
    • Enzyme prodrug gene therapy holds potential for developing more effective bone cancer therapies.
    • Further research into gene therapy is warranted for improving outcomes in bone cancer patients.