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Updated: Aug 15, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
[Structure-functional features of homologous domains of angiotensin-converting enzyme]
S V Voronov1, P V Bineskiĭ, N A Zueva
1Faculty of Chemistry, Moscow State University, Vorob'evy gory, Moscow, 119992 Russia.
Abstract:
Somatic angiotensin-converting enzyme (ACE) consists of two homologous domains, each of them containing an active site. Differences in substrate specificities and affinity to inhibitors of the active sites of the two domains of bovine ACE are described. The ACE domains demonstrate different thermostability, and the reasons for this difference are analyzed. A structural model of the ACE domains is suggested, which allows us to reveal the structural subdomain important for the protein stability and localize the hydrophobic and the carbohydrate-binding sites.
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