Incorporating data received after a sequential trial has stopped into the final analysis: implementation and comparison of methods
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Updated: Aug 30, 2026

Combining Multiple Data Acquisition Systems to Study Corticospinal Output and Multi-segment Biomechanics
Published on: January 9, 2016
Marina Roshini Sooriyarachchi1, John Whitehead, Tatsuru Matsushita
1Department of Statistics, University of Colombo, Sri Lanka.
Abstract:
In a sequential clinical trial, accrual of data on patients often continues after the stopping criterion for the study has been met. This is termed "overrunning." Overrunning occurs mainly when the primary response from each patient is measured after some extended observation period. The objective of this article is to compare two methods of allowing for overrunning. In particular, simulation studies are reported that assess the two procedures in terms of how well they maintain the intended type I error rate. The effect on power resulting from the incorporation of "overrunning data" using the two procedures is evaluated.
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