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Related Experiment Videos

Patterning the peripheral retina of the fly: decoding a gradient.

Andrew Tomlinson1

  • 1Center for Neurobiology and Behavior, Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, Room 1120, New York, NY 10032, USA. at41@columbia.edu

Developmental Cell
|November 7, 2003
PubMed
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Wingless signaling from the fly head organizes peripheral eye specializations. Different Wingless levels specify pigment rims, dorsal rim ommatidia, and hairlessness, with Iroquois genes influencing dorsal development.

Area of Science:

  • Developmental biology
  • Ophthalmology
  • Genetics

Background:

  • The peripheral regions of the fly eye exhibit distinct specializations.
  • These include a pigment rim (PR), dorsal rim (DR) ommatidia, and hairless ommatidia.

Purpose of the Study:

  • To investigate the role of Wingless (Wg) signaling in organizing peripheral eye specializations.
  • To understand the genetic basis for dorsal-specific development of DR ommatidia.

Main Methods:

  • Analysis of gene expression patterns.
  • Observation of ommatidia morphology and function.

Main Results:

  • Wingless (Wg) secreted from the head capsule organizes peripheral eye structures.
  • Higher Wg levels induce PR, intermediate levels induce DR, and lower levels induce baldness.

Related Experiment Videos

  • Exclusive dorsal expression of Iroquois genes predisposes dorsal cells to form DR ommatidia.

    • Conclusions:

    • Wg signaling is a key regulator of peripheral eye patterning in flies.
    • Iroquois genes play a crucial role in dorsal-specific ommatidia development.