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Cholecystokinin, a satiety signal in newborn infants?

G Marchini1, A Lindén

  • 1Department of Pediatrics KS-St Göran, Karolinska Hospital, Stockholm, Sweden.

Journal of Developmental Physiology
|May 1, 1992
PubMed

Insights

Newborn infants show increased cholecystokinin (CCK) levels after breastfeeding, correlating with milk intake. This suggests CCK plays a role in regulating infant feeding behavior and satiety.

Area of Science:

  • Neonatal physiology
  • Gastrointestinal hormones
  • Infant nutrition

Background:

  • Infant feeding behavior is complex, involving hunger and satiety cues.
  • Hormonal regulation of feeding in newborns is not fully understood.

Purpose of the Study:

  • To investigate circulating glucose and cholecystokinin (CCK) levels in relation to feeding behavior in newborn infants.
  • To determine the role of CCK in satiety regulation in neonates.

Main Methods:

  • Studied 83 healthy 3-day-old infants during breastfeeding.
  • Collected blood samples pre-feeding, and at 5, 10 minutes, and post-feeding.
  • Measured plasma glucose and CCK concentrations.

Main Results:

  • Plasma CCK significantly increased 5 and 10 minutes post-sucking initiation and after feeding (P<0.05).
  • A positive correlation was observed between CCK levels and milk intake at 10 minutes (Rs=0.51, P<0.02).
  • No significant changes in glucose concentration were found in relation to breastfeeding.

Conclusions:

  • Cholecystokinin (CCK) may be a key satiety factor in newborn infant feeding.
  • CCK levels rise with milk consumption, signaling fullness to the infant.
  • Glucose levels do not appear to be directly linked to satiety signals during breastfeeding in newborns.

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