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Related Experiment Videos

Spirometric reference values for the 6-s FVC maneuver.

John L Hankinson1, Robert O Crapo, Robert L Jensen

  • 1Hankinson Consulting, Valdosta, GA 31604-3905, USA. hankinson@bellsouth.net

Chest
|November 8, 2003
PubMed
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Reply by Elmaleh-Sachs <i>et al</i>. to Townsend and Cowl, and to Miller <i>et al.</i>

American journal of respiratory and critical care medicine·2022

New reference values for a shorter spirometry test (FVC(6)) are now available. These values are crucial for calculating forced expiratory flow (FEF(25-75%)) in COPD screening, showing significant differences from traditional methods.

Area of Science:

  • Pulmonary Function Testing
  • Respiratory Medicine
  • Spirometry Standardization

Background:

  • The National Lung Health Education Program recommends a shorter forced expiratory volume maneuver (FEV(6)) for COPD screening.
  • Existing reference values for FEV(6) are available, but not for FEF(25-75%) derived from this shorter maneuver.
  • Calculating FEF(25-75%) requires a reference volume, such as FVC(6) from the shortened maneuver.

Purpose of the Study:

  • To derive reference values for spirometry parameters using a shortened 6-second forced expiratory volume maneuver (FVC(6)).
  • To establish reference values for forced expiratory flow between 25% and 75% of FVC(6) (FEF(25-75%6)).
  • To evaluate the utility of FVC(6) as a surrogate for FVC in spirometry.

Main Methods:

  • Reanalyzed raw volume-time data from the third National Health and Nutrition Examination Survey.

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  • Calculated FVC(6), FEV(0.5), FEV(3), FEV(1)/FEV(6)%, and FEF(25-75%6).
  • Derived reference values from a normal, asymptomatic, nonsmoking population (n=7591).

    • Main Results:

    • Analyzed data from 7,591 subjects (2,261 white, 2,564 African-American, 2,666 Mexican-American) aged 8-80 years.
    • New reference values for FVC(6) and FEF(25-75%6) were established.
    • Statistically significant differences were found between FEF(25-75%) and FEF(25-75%6).

    Conclusions:

    • The derived reference values facilitate the evaluation of the shorter FVC maneuver for COPD screening.
    • These values are essential for accurate FEF(25-75%) calculation using the shortened maneuver.
    • The findings highlight the need to use specific reference values for FEF(25-75%6) due to observed differences from traditional FEF(25-75%).