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Scanning probe evolution in biology.

J K H Hörber1, M J Miles

  • 1Department of Physiology, Wayne State University School of Medicine, 5229 Scott Hall, 540 East Canfield Avenue, Detroit, MI 48201, USA.

Science (New York, N.Y.)
|November 8, 2003
PubMed
Summary
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Scanning probe microscopy, including the scanning tunneling microscope, allows visualization of individual atoms and molecules. Ongoing developments aim for real-time, 3D imaging of single-molecule processes.

Area of Science:

  • Nanoscience and Nanotechnology
  • Biophysics
  • Surface Science

Background:

  • The advent of the scanning tunneling microscope (STM) revolutionized scientific perception by enabling visualization of individual atoms.
  • A diverse array of scanning probe instruments (SPIs) has since been developed, extending tactile and imaging capabilities to the atomic and molecular scale.
  • SPIs are crucial for imaging biomolecular structures, offering submolecular resolution in aqueous conditions.

Purpose of the Study:

  • To highlight the impact of scanning probe microscopy on visualizing nanoscale structures.
  • To discuss the evolution and capabilities of scanning probe instruments.
  • To outline future directions in single-molecule imaging.

Main Methods:

  • Utilizing scanning probe instruments for topographic imaging.

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  • Achieving submolecular resolution in aqueous environments.
  • Developing advanced probe configurations for enhanced imaging.

    • Main Results:

    • Scanning probe microscopy transformed abstract atomic concepts into observable realities.
    • SPIs provide high-resolution topographic images of biomolecular structures.
    • Current research focuses on improving imaging rates and reducing probe-specimen forces.

    Conclusions:

    • Scanning probe instruments have fundamentally changed our ability to perceive and interact with matter at the nanoscale.
    • Future advancements promise real-time, three-dimensional imaging of dynamic processes at the single-molecule level, both on surfaces and within volumes.