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[Iodoform poisoning. 3 cases].

P Harry1, G Bouachour, P Tirot

  • 1Centre Anti-Poisons, CHU, Angers, France.

Journal De Toxicologie Clinique Et Experimentale
|March 1, 1992
PubMed
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Iodoform poisoning can occur from wound dressings, causing confusion, hallucinations, and cardiac issues. Symptoms resolve after discontinuing iodoform gauze application.

Area of Science:

  • Toxicology
  • Dermatology
  • Internal Medicine

Background:

  • Iodoform gauze is a topical antiseptic historically used for wound care.
  • Extended wound dressings with iodoform may pose a risk of systemic absorption and toxicity.
  • Understanding iodoform toxicity is crucial for patient safety in clinical practice.

Observation:

  • Three patients developed iodoform poisoning after applying 10% iodoform gauze to extensive wounds.
  • Neurological symptoms (confusion, hallucinations, coma) and cardiac abnormalities (tachycardia, premature ventricular beats, shortened P-R interval) were noted.
  • Other observed signs included vomiting, fever, elevated transaminases, and proteinuria.

Findings:

  • Iodoform toxicity manifested with a distinct clinical presentation involving neurological and cardiovascular systems.

Related Experiment Videos

  • Discontinuation of iodoform dressings led to rapid resolution of toxic signs within 3 to 8 days.
  • The study highlights a potential underrecognition of iodoform toxicity given its historical use and availability.

    • Implications:

    • Clinicians should maintain a high index of suspicion for iodoform toxicity in patients with relevant exposure history.
    • Prompt cessation of iodoform application is key to reversing toxic effects.
    • Further research may be warranted to elucidate the mechanisms and incidence of iodoform poisoning.