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[Clinical trial with barbexaclone in epilepsies]
Arquivos De Neuro-Psiquiatria
|March 1, 1977
Summary
Barbexaclone, a combination of phenobarbital and a central nervous system stimulant, effectively treated epilepsy in children. This open clinical trial found positive outcomes in 82.5% of young patients with Grand Mal seizures.
Area of Science:
- Pediatric Neurology
- Clinical Pharmacology
Background:
- Epilepsy is a common neurological disorder in children.
- Effective and safe treatment options for pediatric epilepsy are crucial.
Purpose of the Study:
- To evaluate the efficacy and safety of barbexaclone in treating epileptic disorders in children.
- To assess treatment outcomes in pediatric patients with Grand Mal seizures.
Main Methods:
- An open-label clinical assay was conducted.
- Forty pediatric patients (0-12 years) with Grand Mal seizures were enrolled.
- Patients received barbexaclone, a combination of phenobarbital and a CNS stimulant.
Main Results:
- Barbexaclone demonstrated satisfactory results in 82.5% of cases.
- Treatment outcomes were categorized as very good or good.
- The study included children with Grand Mal seizures, with or without other epileptic manifestations.
Conclusions:
- Barbexaclone is a potentially effective treatment for pediatric epilepsy.
- The drug showed a high success rate in managing Grand Mal seizures in young patients.