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Updated: Aug 30, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Administration of tacrolimus in 50 liver transplantation patients
Qi-Fa Ye1, Manal Abdel Ruzig, Nian-Qiao Gong
1Institute of Organ Transplantation and Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. yqf_china@sina.com
Objective:
To present a good tacrolimus (FK506) administration protocol in liver transplantation.
Methods:
Fifty liver transplantation patients were classified into FK506 high-concentration (20 patients), FK506 mid-concentration (20), CsA-FK506 (5) and FK506-CsA (5) groups. Clinical manifestations, FK506 side-effects and pathological changes were observed.
Results:
The FK506 high-concentration group showed complications such as infection and liver function damage. The FK506 mid-concentration group showed excellent therapeutic results and some complications easy to deal with.
Conclusion:
FK506 is a highly effective immunosuppressive agent and the mid-concentration protocol is a better one.
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