Serial therapies oriented by surgery for large primary liver carcinoma

Jing-An Rui¹, Shao-Bin Wang, Shu-Guang Chen

¹Department of Liver Surgery, Peking Union Medical College Hospital, Beijing 100032, China. rlzhou@mail.bjmu.edu.cn

Hepatobiliary & Pancreatic Diseases International : HBPD INT

|November 11, 2003

Summary

Serial surgical therapies offer effective treatment for large primary liver cancers, improving survival rates. Monitoring AFPmRNA and using the BCAA/AAA ratio aids in recurrence prediction and pre-operative liver function assessment.

Area of Science:

Hepatobiliary Surgery
Surgical Oncology
Medical Oncology

Background:

Primary liver cancers present significant treatment challenges, particularly large tumors.
Surgical intervention is a cornerstone, but requires multimodal approaches for optimal outcomes.

Purpose of the Study:

To evaluate the efficacy of serial therapies centered on surgery for large primary liver cancers.
To assess survival rates, recurrence patterns, and pre-operative assessment methods.

Main Methods:

191 patients with large liver tumors (mean 9.4 cm) underwent surgical treatment (resection or cryosurgery).
Multimodal therapies included intraoperative drug delivery, transcatheter arterial chemoembolization, percutaneous ethanol injection, bioimmunotherapy, and traditional Chinese medicine.
Diagnostic tools like CT angiography and AFPmRNA monitoring were employed.

Main Results:

1-, 3-, and 5-year survival rates for resection were 75.8%, 45.6%, and 30.4%, respectively.
1- and 3-year survival rates for cryosurgery were 63.2% and 37.0%.
Recurrence rates were significantly higher in AFPmRNA-positive patients (69.2%) versus AFPmRNA-negative (33.3%).

Conclusions:

Serial treatments with surgery as the primary modality yield satisfactory results for large primary liver carcinoma.
AFPmRNA monitoring shows promise for predicting recurrence.
Combined use of BCAA/AAA ratio and Child-Pugh classification improves pre-operative liver function assessment.

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Serial therapies oriented by surgery for large primary liver carcinoma

Area of Science:

Background:

Purpose of the Study:

Main Methods:

Main Results:

Conclusions:

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