Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Neonatal adjustments.

Gordon W Brumbaugh¹

¹Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, TAMU 4466, College Station, TX 77843-4466, USA. gbrumbaugh@cvm.tamu.edu

The Veterinary Clinics of North America. Food Animal Practice

|November 12, 2003

Summary

Neonatal pharmacodynamics mirror adult responses, but altered physiology necessitates dosage adjustments for calves. Careful administration routes and supportive care ensure adequate drug absorption and distribution in critically ill neonates.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Control of bovine respiratory disease, with and without co-morbidity by otitis media, in dairy heifers comparing gamithromycin, tulathromycin, or no medication at a commercial development facility.

Journal of dairy science·2019

Same author

Will antimicrobial resistance of BRD pathogens impact BRD management in the future?

Animal health research reviews·2014

Same author

Serologic response to Mannheimia haemolytica in calves concurrently inoculated with inactivated or modified-live preparations of M. haemolytica and viral combination vaccines containing modified-live bovine herpesvirus type 1.

American journal of veterinary research·2011

Same author

In vitro activities of tulathromycin and ceftiofur combined with other antimicrobial agents using bovine Pasteurella multocida and Mannheimia haemolytica isolates.

Veterinary therapeutics : research in applied veterinary medicine·2008

Same author

Melengestrol acetate as a tool for inducing early ovulation in transitional mares.

Acta veterinaria Hungarica·2008

Same author

Pharmacokinetics and clinical effects of a subanesthetic continuous rate infusion of ketamine in awake horses.

American journal of veterinary research·2006

Area of Science:

Veterinary Pharmacology
Neonatal Physiology
Drug Metabolism

Background:

Neonatal patients exhibit unique physiological characteristics.
Pathophysiological changes in neonates can significantly alter drug processing.
Standard adult dosage regimens may not be suitable for neonatal calves.

Purpose of the Study:

To highlight the pharmacokinetic differences in neonates compared to adults.
To emphasize the need for adjusted dosage regimens in neonatal calves.
To discuss the impact of administration routes and supportive care on drug efficacy in neonates.

Main Methods:

Comparative analysis of neonatal and adult pharmacodynamics.
Evaluation of physiological and pathophysiological influences on pharmacokinetics.

Related Experiment Videos

Assessment of drug administration routes and formulation effects.

Main Results:

Pharmacodynamic responses are similar between neonatal and adult patients.
Physiologic and pathophysiologic changes necessitate pharmacokinetic adjustments.
Intravenous administration may be critical for critically ill neonates.
Anatomical site and product formulation impact absorption and clinical response.

Conclusions:

Dosage regimens for neonatal calves require adjustments due to pharmacokinetic variations.
Adjunctive care is vital for optimizing drug absorption and distribution.
Route of administration and formulation are critical factors for neonatal treatment success.