On simulating strongly-interacting, stochastic population models
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Updated: Aug 30, 2026

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling
Published on: July 4, 2007
1Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, 1100 Olive Way, 5th Floor, Seattle, WA 98101, USA. wick@sharp.org
Abstract:
Simulating strongly-interacting biological populations over many orders-of-magnitude can be challenging even on fast modern computers. Here we describe a regime-switching technique that can speed up simulations from stochastic models by large factors, while retaining third-order accuracy at each time-step. We apply it to an elementary model of the immune response to an infectious organism.
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