Related Experiment Video
Updated: Aug 30, 2026

Calibration Procedures for Orthogonal Superposition Rheology
Published on: November 18, 2020
Use of the orthogonal projection approach (OPA) to monitor batch processes
S Gourvénec1, C Lamotte, P Pestiaux
1ChemoAC, Pharmaceutical Institute, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussel, Belgium.
Abstract:
The orthogonal projection approach (OPA) and multivariate curve resolution (MCR) are presented as a way to monitor batch processes using spectroscopic data. Curve resolution allows one to look within a batch and predict on-line real concentration profiles of the different species appearing during reactions. Taking into account the variations of the process by using an augmented matrix of complete batches, the procedure explained here calculates some prediction coefficients that can afterwards be applied for a new batch.

