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Proteinuria in diabetic nephropathy: treatment and evolution
Ruth C Campbell1, Piero Ruggenenti, Giuseppe Remuzzi
1Division of Nephrology and Dialysis, Ospedali Riuniti di Bergamo and Mario Negri Institute for Pharmacological Research, Negri Bergamo Laboratories, Via Gavazzeni, 11, Bergamo 24125, Italy.
Current Diabetes Reports
|November 13, 2003
Summary
Diabetic nephropathy, marked by kidney function loss and proteinuria, can be managed. A multidisciplinary approach optimizing metabolic and hypertensive control, alongside specific medications, effectively halts disease progression.
Area of Science:
- Nephrology
- Endocrinology
- Diabetology
Background:
- Diabetic nephropathy involves increased urinary albumin excretion and renal function decline.
- Proteinuria is a hallmark of diabetic nephropathy, historically leading to end-stage renal disease and increased mortality.
- Effective treatments are available to prevent, slow, or reverse diabetic nephropathy.
Purpose of the Study:
- To review current and emerging strategies for managing diabetic nephropathy.
- To emphasize the importance of a multidisciplinary approach in halting disease progression.
Main Methods:
- Review of current clinical trials and treatment guidelines.
- Focus on optimizing metabolic and hypertensive control.
- Inclusion of angiotensin-converting enzyme inhibitors or angiotensin 2 receptor antagonists in treatment regimens.
Main Results:
- A multidisciplinary approach combining metabolic and hypertensive control with specific medications is effective.
- These strategies can halt the progression of diabetic renal disease.
Conclusions:
- Optimizing metabolic and hypertensive control is crucial for managing diabetic nephropathy.
- The use of ACE inhibitors or ARBs is a key component of effective treatment.
- Widespread screening and implementation of these strategies are necessary to combat the epidemic of diabetic renal disease.