Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Human molecular genetics: from monogenic to polygenic or complex disorders].

François Rousseau1, Nathalie Laflamme

  • 1Unité de recherche en génétique humaine et moléculaire, Centre de recherche de l'hôpital St-François-d'Assise du CHUQ, Université Laval, 10, rue de l'Espinay, Québec G1L 3L5, Canada.

Medecine Sciences : M/S
|November 13, 2003
PubMed
Summary

Identifying genes for complex traits is the next frontier in human molecular genetics. This research addresses the methods, challenges, and clinical applications of discovering these genetic determinants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enrichment of Fetal Cell-Free DNA in Early Miscarriages for Detection of Aneuploidy: A Novel Approach.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same author

Homozygous familial hypercholesterolemia (HoFH) in Canada.

Atherosclerosis·2026
Same author

Comparison of different "familial chylomicronemia syndrome" clinical diagnosis scoring systems in patients with persistent chylomicronemia.

Journal of clinical lipidology·2026
Same author

Quantitative comparison of explainable AI methods for interpreting deep learning-based classification of 3D gait kinematics.

Scientific reports·2026
Same author

Validation of PREM-PS, a patient-reported experience instrument, in a randomized controlled trial of pregnant women undergoing prenatal screening.

Journal of patient-reported outcomes·2026
Same author

Assessment of pregnant women's intention to use a mobile application-based decision aid for prenatal screening for trisomies 21, 18 and 13: A mixed-methods cross-sectional study.

Patient education and counseling·2026

Area of Science:

  • Human molecular genetics
  • Genomics
  • Complex trait genetics

Context:

  • Monogenic disorders have been largely elucidated genetically.
  • The field is shifting towards complex traits with significant genetic components.
  • New methodologies are required to address this shift.

Purpose:

  • To discuss the methodological and practical aspects of identifying genes for complex traits.
  • To highlight the challenges in this area of genetic research.
  • To consider the implications for physicians using new diagnostic tools.

Summary:

  • Human molecular genetics has progressed from identifying single-gene disorders to tackling complex traits.
  • This involves new challenges in gene discovery for polygenic conditions.

Related Experiment Videos

  • The paper reviews the approaches and hurdles in this evolving field.

    • Impact:

    • Advances the understanding of genetic architecture of complex diseases.
    • Provides insights into the clinical utility of polygenic genetic testing.
    • Prepares physicians for the integration of complex trait genetics into diagnostics.