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Updated: Aug 30, 2026

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
Published on: May 30, 2013
Does folinic acid have a choleretic effect on humans?
Feza Y Karakayali1, Sancar Bayar, Selçuk Hazinedaroğlu
1Department of Surgery, Faculty of Medicine, Ankara University, Ankara, Turkey. fezaykar@yahoo.com
Background/Aims:
The aim of this study was to clarify whether folinic acid has any choleretic effect in humans, as observed by Kajiyama et al. in both clinical and experimental studies.
Methods:
The choleretic effect of folinic acid was analyzed prospectively in a subgroup of patients who had external biliary catheters with periampullary tumors causing complete biliary obstruction. Folinic acid (50mg/day) was administered twice with a 24-hour interval between each dose. Daily bile volume was then recorded on the three consecutive days following the first dose of folinic acid. Mean bile flows (basal output=mean bile volume of four days) before and after (fifth, sixth and seventh days) the initiation of folinic acid administration were then compared.
Results:
Mean bile volumes were determined as baseline output: 669.20+/-235.18, 5th day=: 668.63+/-235.26, sixth day: 670.45+/-235.08, and seventh day: 670.00+/-235.11. No significant difference in daily bile volumes before and after folinic acid administration was detected (p>0.05).
Conclusion:
No choleretic effect of intravenous folinic acid administration was observed in this prospective clinical study. This finding was contrary to our previous study on this subject.
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