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Does folinic acid have a choleretic effect on humans?
Feza Y Karakayali1, Sancar Bayar, Selçuk Hazinedaroğlu
1Department of Surgery, Faculty of Medicine, Ankara University, Ankara, Turkey. fezaykar@yahoo.com
Summary
This study found that intravenous folinic acid does not have a choleretic effect in humans. Bile volume measurements showed no significant change after folinic acid administration, contrary to previous research.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Previous studies suggested folinic acid may possess choleretic properties.
- Clinical and experimental evidence by Kajiyama et al. indicated a potential choleretic effect.
Purpose of the Study:
- To investigate the choleretic effect of folinic acid in human subjects.
- To validate or refute previous findings on folinic acid's impact on bile production.
Main Methods:
- Prospective analysis in patients with external biliary catheters and periampullary tumors.
- Administration of folinic acid (50mg/day) with a 24-hour interval.
- Measurement of daily bile volume for three days post-administration and comparison with baseline.
Main Results:
- Mean bile volumes showed no statistically significant difference before and after folinic acid administration (p>0.05).
- Baseline bile output averaged 669.20+/-235.18 mL.
- Post-administration bile volumes on days 5, 6, and 7 were 668.63+/-235.26, 670.45+/-235.08, and 670.00+/-235.11 mL, respectively.
Conclusions:
- Intravenous folinic acid administration demonstrated no choleretic effect in this human clinical study.
- The findings contradict earlier experimental and clinical observations.
- Further research may be needed to fully understand folinic acid's physiological effects.