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Ureteropelvic junction obstruction causes histologic alterations in contralateral kidney
Saniye Ekinci1, Arbay O Ciftci, Pergin Atilla
1Department of Pediatric Surgery, Hacettepe University Medical Faculty, Ankara, Turkey.
Journal of Pediatric Surgery
|November 14, 2003
Summary
Ureteropelvic junction (UPJ) obstruction causes kidney damage in both affected and unaffected kidneys. Complete obstruction led to more severe histologic changes, including apoptosis, in the contralateral kidney.
Area of Science:
- Nephrology
- Experimental Pathology
- Urology
Background:
- Ureteropelvic junction (UPJ) obstruction induces histological changes in both ipsilateral and contralateral kidneys.
- Understanding these changes is crucial for managing renal damage progression.
Purpose of the Study:
- To investigate the renal histological alterations resulting from partial and complete UPJ obstruction.
- To compare the effects of different degrees of UPJ obstruction on kidney histology.
Main Methods:
- Adult female New Zealand rabbits were divided into three groups: sham operation (control), partial UPJ obstruction, and complete UPJ obstruction.
- Histological tissue processing was performed on samples from ipsilateral and contralateral kidneys.
- Animals were observed for 2 or 3 weeks post-obstruction.
Main Results:
- Ipsilateral kidneys showed glomerulosclerosis, tubular dilatation, and necrotic/apoptotic changes.
- Contralateral kidneys exhibited glomerular edema, vascular congestion, tubular dilatation, and epithelial necrosis/apoptosis.
- These contralateral changes were more severe in the complete UPJ obstruction group.
Conclusions:
- The study confirmed progression of parenchymal damage and apoptosis in the contralateral kidney due to UPJ obstruction.
- This finding is significant as it demonstrates damage in the contralateral kidney, contrary to expected compensatory changes.