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Corticosteroid allergy in asthma.

K Kilpiö1, M Hannuksela

  • 1Department of Pulmonary Diseases, South Karelia Central Hospital, Lappeenranta, Finland.

Allergy
|November 18, 2003
PubMed
Summary
This summary is machine-generated.

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Corticosteroid allergy is occasionally seen in asthma patients experiencing side effects from inhaled corticosteroids. While cross-reactivity is common, alternative corticosteroids are often tolerated, suggesting careful selection is key for managing asthma.

Area of Science:

  • Dermatology
  • Pulmonology
  • Allergology

Background:

  • Glucocorticosteroids are primary treatments for asthma and allergic conditions.
  • These medications can paradoxically induce delayed or immediate allergic reactions.
  • Investigating corticosteroid allergy is crucial for patients with asthma experiencing adverse effects.

Purpose of the Study:

  • To determine the prevalence of corticosteroid allergy in asthma patients.
  • To evaluate allergic reactions in patients with side effects from inhaled corticosteroids.

Main Methods:

  • Patch testing was conducted on 51 asthma patients with side effects and 50 symptom-free controls.
  • A range of corticosteroids including betamethasone, hydrocortisone, budesonide, beclomethasone, and fluticasone were tested.

Related Experiment Videos

  • Test results were evaluated at two time points: Day 4-5 and Day 10.

    • Main Results:

    • Two symptomatic patients showed positive patch test reactions to specific corticosteroids.
    • One patient developed eczematous dermatitis with beclomethasone and experienced throat/breathing issues with fluticasone.
    • The second patient had a severe rash with budesonide, despite tolerating topical steroids for atopic dermatitis.

    Conclusions:

    • Delayed corticosteroid allergy occurs in asthma patients, similar to dermatitis prevalence.
    • Positive patch tests indicate clinical allergy, necessitating avoidance of the specific steroid.
    • Cross-allergy among corticosteroids is frequent, but alternative steroids are often well-tolerated.