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Beta-trace protein as sensitive marker for CSF rhinorhea and CSF otorhea
H Reiber1, K Walther, H Althaus
1Neurochemisches Labor, Universität Göttingen, Goettingen, Germany. h.reiber@med.uni-goettingen.de
Acta Neurologica Scandinavica
|November 18, 2003
Summary
A new assay accurately measures beta-trace protein in cerebrospinal fluid (CSF) and secretions. This method reliably detects CSF leaks, such as CSF rhinorrhea or otorrhea, aiding in diagnosis.
Area of Science:
- Biochemistry
- Clinical Diagnostics
- Neurology
Background:
- Beta-trace protein (BTP) is a biomarker found in cerebrospinal fluid (CSF).
- Accurate quantification of BTP is crucial for diagnosing CSF leaks.
Purpose of the Study:
- To evaluate a new quantitative immunonephelometric assay for BTP.
- To establish reference ranges and diagnostic cut-offs for BTP in various bodily fluids.
Main Methods:
- A novel quantitative immunonephelometric assay was employed.
- BTP concentrations were measured in CSF, serum, and nasal secretions from control subjects and patients with confirmed CSF leaks.
Main Results:
- Normal CSF BTP (18.4 mg/l) and serum BTP (0.59 mg/l) were established in 132 controls.
- Nasal secretion BTP in controls was very low (median 0.016 mg/l).
- CSF rhinorrhea cases (n=20) showed elevated BTP (median 2.4 mg/l), with a proposed cut-off of 0.35 mg/l for detecting CSF contamination.
Conclusions:
- The new BTP assay is sensitive, fast, and reliable for routine use.
- It effectively aids in diagnosing CSF rhinorrhea and otorrhea.