Supplemental perioperative oxygen and fluids to improve surgical wound outcomes: Translating evidence into practice

Numerous reports support the concept that tissues require an adequate oxygen supply to heal well and to prevent complications of infection. Adequate oxygen supply to tissue depends on perfusion as well as arterial oxygen tension, and tissue oxygen tension, particularly in peripheral tissues, is dependent on adequate vascular volume. Therefore, potential benefits to wound healing and reduction in infection in postsurgical patients might be attained by judicious manipulation of supplemental oxygen and/or fluids in the perioperative period. This article reviews evidence that suggests such manipulations are beneficial and proposes that integrated care pathways be developed that include these interventions.