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Updated: Aug 30, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Chromosomal mosaicism on amniotic interphase nuclei detected by multiprobe FISH
Maria Constantinou1, Ewa Zajac, Bogdan Kałuzewski
1Department of Medical Genetics, Medical University of Łódź, Łódź, Poland. majcon@kardio-sterling.lodz.pl
Abstract:
So far classical prenatal detection of chromosome aberrations has been limited to the evaluation of metaphase by means of time-consuming cytogenetic techniques. The MultiVision PGT test enables a simultaneous detection of aneuploidies of chromosomes 13,18, 21, X, and Y, even 24 h after amniocentesis. In the presented case, this test detected prenatally a chromosomal mosaicism 69,XYY[35]/46,XY[65]. This result was not confirmed after birth, by the same test on blood smear. The discrepancy is difficult to explain.
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