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[Determination of ethanol concentration in tinctures]
Jurga Bernatoniene1, Rūta Bernatoniene, Algis Baranauskas
1Department of Pharmacy, Kaunas University of Medicine, A. Mickeviciaus 9, 3000 Kaunas, Lithuania.
Medicina (Kaunas, Lithuania)
|November 18, 2003
Summary
This study compared three methods for determining alcohol content in tinctures. The P. Balovoine method, utilizing dry residue and relative density, proved most effective for accurate ethanol concentration measurement.
Area of Science:
- Pharmaceutical Chemistry
- Analytical Chemistry
Background:
- Accurate determination of ethanol concentration in tinctures is crucial for quality control.
- Existing methods for alcohol determination may vary in precision and applicability.
Purpose of the Study:
- To experimentally verify and compare three distinct methods for determining alcoholic strength in tinctures.
- To identify the most reliable and accurate method for ethanol concentration analysis in tinctures.
Main Methods:
- Comparative analysis of three techniques: distillation, G. K. Koliakova's method, and P. Balovoine's method.
- Experimental verification of each method's performance.
- Evaluation based on accuracy and practicality for tincture analysis.
Main Results:
- All three methods were evaluated for their efficacy in determining ethanol concentration.
- The P. Balovoine method demonstrated superior performance compared to distillation and G. K. Koliakova's method.
- The P. Balovoine method's reliance on dry residue and relative density provides a robust measure.
Conclusions:
- The P. Balovoine method is recommended as the optimal technique for determining ethanol concentration in tinctures.
- This method offers enhanced accuracy for alcoholic strength assessment in pharmaceutical preparations.