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[Features of clinical course of enteric fever associated with polyresistant strains of Sp.typhi 61-0 ]

N M Norboev, M D Akhmedova, I Kh Mamatkulov

    Likars'Ka Sprava
    |November 19, 2003
    PubMed

    Insights

    This study examines abdominal typhoid caused by multidrug-resistant Salmonella Typhi 61-0 strains. These infections present with severe symptoms and a higher risk of complications, making Widal's reaction unreliable for diagnosis.

    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Clinical Medicine

    Background:

    • Antibiotic resistance in Salmonella Typhi is a growing global health concern.
    • Multidrug-resistant strains of Salmonella Typhi can lead to more severe typhoid fever cases.
    • Understanding the clinical presentation of infections caused by specific resistant strains is crucial for effective management.

    Purpose of the Study:

    • To investigate the clinical features of abdominal typhoid fever caused by the multidrug-resistant Salmonella Typhi 61-0 strain.
    • To assess the frequency of complications associated with this specific strain.
    • To evaluate the diagnostic utility of Widal's reaction in cases of Salmonella Typhi 61-0 infection.

    Main Methods:

    • Retrospective clinical analysis of patients diagnosed with abdominal typhoid fever.
    • Identification and characterization of Salmonella Typhi strains, focusing on polyresistance.
    • Correlation of clinical data with microbiological findings and diagnostic test results.

    Main Results:

    • Salmonella Typhi 61-0 polyresistant strain-associated enteric fever typically presents as a moderately severe to severe illness.
    • Patients infected with this strain exhibit an increased incidence of complications, including intestinal hemorrhage, intestinal perforation, and pneumonia.
    • Widal's reaction demonstrated limited diagnostic expediency in the context of Salmonella Typhi 61-0 strain infections over time.

    Conclusions:

    • The Salmonella Typhi 61-0 polyresistant strain is associated with a more severe clinical course and higher complication rates in abdominal typhoid.
    • Clinical vigilance for complications like hemorrhage, perforation, and pneumonia is essential in managing these infections.
    • The diagnostic reliability of Widal's reaction is questionable for Salmonella Typhi 61-0 strain-induced typhoid fever, necessitating alternative diagnostic approaches.

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