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Membrane-associated phospholipase A2 stimulates DNA synthesis in two murine fibroblasts
T Kurizaki1, H Egami, K Murata
1Department of Surgery II, Kumamoto University Medical School, Japan.
Research Communications in Chemical Pathology and Pharmacology
|October 1, 1992
Abstract:
The effect of human membrane-associated phospholipase A2 (M-PLA2) on DNA synthesis in fibroblasts was examined in order to clarify its biological function. Human M-PLA2 added exogenously to the fibroblast cell lines Swiss 3T3 and BALB/3T3 was found to augment their DNA synthesis. This stimulation of DNA synthesis was not affected by treatment with indomethacin. Our results suggest that human M-PLA2 itself has a mitogenic effect on fibroblasts independent of arachidonate products such as prostaglandins.